Latent Space: The AI Engineer Podcast

Katelyn Lesse and Angela Jiang join Latent Space to explain the engineering behind the Claude Platform: launching Opus 5.5, separating the model’s “brain” from the agent’s “hands,” scaling APIs, and building reliable managed agents. A…

AI agents are creating more software—and that changes what a backend needs to do. Supabase co-founders Paul Copplestone and Ant Wilson join swyx to discuss running long-lived workloads alongside the database, making schemas easier for agents to underst...

Watch the full show on YouTube: https://www.youtube.com/watch?v=vhPCo-8K78U

Warm welcome to Basil Chatha, our newest cohost from the Forward Deployed side of the AI Engineering world! We’ll be ramping up a new show with him and couldn’t pass up an interview with Modal’s CEO Eric on the occasion of their monster Series D! Two y...

Anekha Sokhal, CEO of Moshi, joins swyx to discuss building a recommendation engine for commodity traders, turning market data into useful signals, and designing AI that fits users’ workflows. Watch: YouTube · Moshi · Anekha 0:00 AI Engineer New York a...

Alex Lieberman and CJ Hess join swyx at AI Engineer New York to discuss Tenex’s approach to AI-native engineering, paying for outcomes, MetaHarness, enterprise AI adoption and rebuilding SaaS. Show notes: Tenex: https://www.tenex.co/ Building an AI-native SDLC:…

This was recorded on the sidelines of the new Compute Trading track at AIE NYC . Catch us next at AIE CODE , our last flagship for the top agentic engineers in the world. In the early days of cloud, former guest Martin Casado made something so disruptive that Cisco was…

A few years ago I stumbled upon Leash Bio’s Substack , and was hooked. Be it their Kaggle competition that showed that no, we really haven’t solved protein-ligand binding , or their crazy discovery that knowing a molecule’s author is perhaps all you need to know to predict how…

Watch along AIE NYC and join us at AIE CODE in SF next month! This episode includes a live demo of the Taku robot that is best enjoyed on YouTube . Last month, Dyna made waves by announcing Dyna-2 , a world-action model pre-trained on one million hours of human video, claiming…

From the Bitter Lesson of AI scaling to the unsolved mysteries of protein folding , Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido are rethinking what it takes to build AI that truly understands biology. In this special panel moderated by Brandon Anderson , they…

It’s hard to believe that Periodic was only launched last September : One year later, it is considered one of the pre-eminent AI scientist labs, with dizzying talent density and astonishing progress in the autonomous lab buildout: Most people are familiar with the standard…

Watch the full show on YouTube: https://www.youtube.com/watch?v=MWX36ZYnsm0

Last call for regular tickets for AI Engineer NYC ! As an exclusive for Latent Space subscribers, the first 30 of you can take a 30% off code if it helps - for new tickets only, no refunds! See you in 2 weeks! While we tend to cover industry on the pod, every so often we…

Three months ago Dwarkesh, who has been posting incredible blogs and episodes about RL, posted a framing question for his video essay on RLVR which upset a lot of Computer Use folks: We are no strangers to learning in public and are no strangers to the stress of getting things…

We are excited to have Anthropic share their latest AI x Finance work at AI Engineer New York , coming up in 2 weeks! In case you’ve been under a rock, here’s a non-exhaustive list of what Anthropic has been shipping since closing the largest fundraise of all time in May at $47B…

From the earliest days of open-weight models to becoming the neutral routing layer for more than 10 million developers , OpenRouter is one of the clearest bets that the future of AI will be multi-model. In this episode, OpenRouter co-founder & CEO Alex Atallah, with AMP’s Anjney…

Earlier this month, world model company Runway introduced GWM Worlds 2 , a research preview that “turns high-fidelity video and audio generation into real-time interactive simulation .” Runway calls this an “autoregressive diffusion” model; with autoregressive describing how it…

The OpenAI → Hugging Face attack has people asking “what else do we need to worry about?” and Anthropic’s filters flag two things: cyber-security and biology. The natural question is: what about bio-security, then? Clem Delangue argues that cyber-warfare defensive capabilities…

How often do you get to talk to a guest who has both an Academy Award and who invented textbook machine learning algorithms? John Platt has an Oscar , two textbook algorithms , two named asteroids, and an Erdos-Bacon number of 6. This was easily the most fun bio of all the…

Tickets for AIE NYC now open, and apply for the invite-only AIE CODE . Join us ! We have an unusual relationship with today’s guest: for years since coauthoring the InstructGPT paper , Diogo Almeida had been saying that API-available frontier models have been going down the…

Watch the full show on YouTube: https://www.youtube.com/watch?v=V_9TCu_21SE

AIUC first got our attention with the NFDG backing, and have just announced a $40M series A today, with the most impressive industry advisor list we may have ever seen for an early startup behind AIUC-1 , their agent standard backed by real insurance: From being Anthropic’s…

At 1:09:00 we talk about the rise of AI x Finance, and AIE NYC is one month away - our hotel block is 97% sold out, get tix & travel ASAP - we will announce speakers from Bridgewater, Ramp, Coatue, Mastercard, Vanguard, Coinbase, Blackrock, Fidelity, Point72, Capital One, JPMC,…