🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

The OpenAI → Hugging Face attack has people asking “what else do we need to worry about?” and Anthropic’s filters flag two things: cyber-security and biology. The natural question is: what about bio-security, then? Clem Delangue argues that cyber-warfare defensive capabilities need to be open and to keep pace with frontier models’ attack capabilities Radical Numerics co-founder Eric Nguyen sat down with us and explained why the same models that increase biological capability can also keep defense from falling behind. Building a virus from scratch While he was at Stanford, Eric couldn’t get traction on Genomic Language Models (GLMs) for a long time. Biologists didn’t believe it would work, didn’t think they could verify the output, and didn’t see important applications beyond what they could already do. He kept pushing, eventually helping lead the development of Evo and contributing to Evo 2 at Arc Institute. Those models were later used by a separate Arc/Stanford team to generate entire bacteriophage genomes that were synthesized into functional viruses ! Long context unlocks biological intelligence Early ChatGPT spit out poems and email, and early DNA language models like Evo and Evo-2 could build a genome from scratch. DNA is different, however, from natural language in that it has a very small alphabet (4 characters ACTG) and that its sequences are very long: * 60K for an average human gene * long being up to 2.3M * the whole human genome around 3B. Innovation in long-context models made this possible about 3 years ago (footnote: striped hyena), long before the frontier labs were building 1M+ context models. Now Eric and other AI x Bio luminaries have founded Radical Numerics to build and scale GLMs to tack a wide range of biological problems, extending well beyond generating DNA. Thinking in DNA Their GLMs already do pretty well with RNA and protein because there are clear markers in the DNA sequence for genes (RNA sequences the perform many functions) and speci